Brand name: Samsca


Samsa is indicated for slowing the decline in kidney function in adults at risk of rapid progression of autosomal dominant polycystic kidney disease
Brands: Samsca
Availability: Prescription needed
Pregnancy: Consult a doctor
Alcohol: Alcohol will slow down the absorption of the drug into the blood
Side Effects: Dry Mouth, Persistent Bleeding Or Oozing From Puncture Sites, Mouth, Or Nose, Bloody Stools
Interactions: Avonex (interferon Beta-1a), Methotrexate, Aldactone (spironolactone)
For informational purposes only. Consult your local medical authority for advice.

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You should not use tolvaptan if you are allergic to it, or if:

  • you are unable to urinate;
  • you are unable to tell that you are thirsty;
  • you are severely dehydrated and feel like you might pass out; or
  • you have autosomal dominant polycystic kidney disease (unless you receive tolvaptan through a special program that includes frequent liver function tests).

Some medicines can cause unwanted or dangerous effects when used with tolvaptan. Your doctor may change your treatment plan if you also use:

  • nefazodone;
  • an antibiotic--clarithromycin, telithromycin;
  • antifungal medicine--itraconazole, ketoconazole; or
  • HIV/AIDS medication--indinavir, nelfinavir, ritonavir, saquinavir.

Tell your doctor if:

  • you have kidney disease or urination problems;
  • you have liver disease (especially cirrhosis);
  • you also take desmopressin (dDAVP), or a diuretic or "water pill";
  • you are malnourished; or
  • you have been drinking large amounts of alcohol.

It is not known whether tolvaptan will harm an unborn baby. Tell your doctor if you are pregnant.
It may not be safe to breast-feed while using Samsca. Ask your doctor about any risk.

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